Big Bill is a nickname that may refer to:

• Bill Abstein (1883–1940), American Major League Baseball and amateur soccer player
• Bill Bachrach (1879–1959), American swim and water polo coach
• Bill Bagwell (1895–1976), American Major League Baseball player
• Big Bill Bissonnette (1937–2018), American jazz trombonist and producer
• Big Bill Broonzy (1903–1958), American blues singer and guitarist
• William Stephen Devery (1854–1919), New York City Police superintendent and first police chief, later co-owner of the New York Yankees baseball team
• Bill Dwyer (mobster) (1883–1946), prohibition gangster and bootlegger
• Big Bill Edwards (1877–1943), American college football player
• Bill France Sr. (1909–1992), American racing driver, co-founder, Chairman and CEO of NASCAR
• Bill Gatewood (1881–1962), American Negro league baseball player and manager
• Bill Haywood (1869–1928), a prominent figure o…Read more on Wikipedia